Skeletal muscle transcriptional networks linked to type I myofiber grouping in Parkinson’s disease

Myofiber Remodeling of Rabbit Skeletal Muscle

Sustained contractile activity of skeletal muscle promotes angiogenesis, as well as transformation of contractile protein isoforms and mitochondrial proliferation within myofibers. Since the products of immediate early genes such as c-fos, c-jun, and egr-1 function in many signaling pathways governing cellular responses to external stimuli, we sought to determine whether sustained contractile a...

Human skeletal muscle fibre type grouping and collateral re-innervation.

Transcriptional regulation of IGF-I expression in skeletal muscle.

The present study investigated the role of transcription in the regulation of insulin-like growth factor (IGF)-I expression in skeletal muscle. RT-PCR was used to determine endogenous expression of IGF-I pre-mRNA and mRNA in control (Con) and functionally overloaded (FO) rat plantaris. The transcriptional activities of five different-length IGF-I promoter fragments controlling transcription of ...

Niacin supplementation induces type II to type I muscle fiber transition in skeletal muscle of sheep

BACKGROUND It was recently shown that niacin supplementation counteracts the obesity-induced muscle fiber transition from oxidative type I to glycolytic type II and increases the number of type I fibers in skeletal muscle of obese Zucker rats. These effects were likely mediated by the induction of key regulators of fiber transition, PPARδ (encoded by PPARD), PGC-1α (encoded by PPARGC1A) and PGC...

Manifold-driven Grouping of Skeletal Muscle Fibers

In this report, we present a manifold clustering method for the classification of fibers obtained from diffusion tensor images (DTI) of the human skeletal muscle. To this end, we propose the use of angular Hilbertian metrics between multivariate normal distributions to define a family of distances between tensors that we generalize to fibers. The obtained metrics between fiber tracts encompasse...